Mustard gas toxicity

Mustard gas toxicity

 

The use of mustard agents in warfare, particularly sulphur mustard, dates back to the First World War and during recent years has caused death and suffering among both combatants and civilians in Iran. The exact mechanisms by which sulphur mustard exerts is numerous and debilitating toxic effects have been investigated in many laboratories but no clear picture has emerged. Until these mechanisms are fully understood, approaches to prevention and treatment of the toxic effects of such agents will lack a rational basis and are likely to be inefficient. We have conducted exhaustive reviews of the field and as a result a more complete account of the toxic mechanisms has emerged.

 

Ghabili K, Agutter PS, Ghanei M, Ansarin K, Panahi Y & Shoja MM (2011) Sulfur mustard toxicity: history, chemistry, pharmacokinetics, and pharmacodynamics. Crit Rev Toxicol 41, 384-403. PMID: 21329486

 

 

Ghabili K, Agutter PS, Ghanei M, Ansarin K & Shoja MM (2010) Mustard gas toxicity: the acute and chronic pathological effects. J Appl Toxicol 30, 627-643. PMID: 20836142

 

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